SIGNIFICANCE OF THE HEMOSIDEROSIS OF PERNICIOUS ANEMIA
نویسندگان
چکیده
منابع مشابه
Significance of the Hemosiderosis of Pernicious Anemia
The selective deposition of hemosiderin in the liver parenchyma during pernicious anemia does not constitute evidence that there is a hemolytic cause for the disease located in the portal region. The repeated introduction of small amounts of free hemoglobin into the general circulation, by the subcutaneous route, leads, as we have shown, to an identical siderosis. Larger amounts of hemoglobin c...
متن کاملOptimal management of pernicious anemia
Pernicious anemia (also known as Biermer's disease) is an autoimmune atrophic gastritis, predominantly of the fundus, and is responsible for a deficiency in vitamin B12 (cobalamin) due to its malabsorption. Its prevalence is 0.1% in the general population and 1.9% in subjects over the age of 60 years. Pernicious anemia represents 20%-50% of the causes of vitamin B12 deficiency in adults. Given ...
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T HE climmical emitity, permmicious anenmia, is the result. of a prolousged deficiency jut vitamimm 1312. While there is a gemmeral abnornmality throughout the body ins cellular growth ammd immetabolismmm,’ the effects of the deficiemmcy are readily denmoumstrated by the nmegaloblast.ic changes of the erythron. The mmmaummmer iui ivhich ammemia is produced seems imicreasingly complex as nmore d...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1922
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.35.4.521